Patexia. Community

Our Members

All »
Feb 9, 2012
Metastatic breast cancer hitches a free ride from the immune system
Share this article

Inflammatory breast cancer (IBC) spreads easily through the lymphatic and blood vessels, forming deadly metastasis. New research demonstrates how IBC cells use IL-8, a compound secreted as part of the anti-inflammatory response by a specific set of white blood cells (monocytes), to increase fibronectin expression. Fibronectin is a cell-adhesion molecule usually involved in wound healing and cell migration, but over-expression of this molecule is thought to allow cancer to metastasize. Prof Mona Mohamed from Cairo University used a cytokine antibody array to identify which immune-regulating molecules were secreted by monocytes and found that, while monocytes secreted a small amount each of a wide range of molecules, there was up to 10 times more IL-8 and MCP-1. The cocktail of immune-regulating molecules from the monocytes was able to increase the amount of fibronectin produced in IBC cells and in 3D culture produced branch-like structures typical of fibronectin over-expression.

Relevant Locations: 1466, South Africa
1467 Copenhagen, Denmark
Comment (0) Favorite (0)
Be the first to comment.