Patexia. Research
Patent No. US 08124646
Issue Date Feb 28, 2012
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Patent 08124646 - Substituted isoindoline-1,3-dione derivatives > Claims

  • 1. A compound of Formula I:
    • 2. The compound of claim 1, wherein Y6, Y7 and Y8 are the same; Y1a and Y1b are the same; and Y3, Y4 and Y5 are the same.
      • 4. The compound of claim 2, wherein the compound of Formula I is a compound of Formula Ia, having predominantly the (S) configuration at the carbon attached to Y2:
      • 5. The compound of claim 2, wherein the compound of Formula I is a compound of Formula Ia, having predominantly the (R) configuration at the carbon attached to Y2:
    • 3. The compound of claim 1, wherein the compound of Formula I is a compound of Formula II:
    • 6. The compound of claim 1, wherein Y6, Y7 and Y8 are the same.
    • 7. The compound of claim 1, wherein Y1a and Y1b are the same.
    • 8. The compound of claim 1, wherein Y3, Y4 and Y5 are the same.
    • 9. The compound of claim 1, wherein R1 is CH3 or CD3.
    • 10. The compound of claim 1, wherein R4 is CD2CD3.
    • 15. A compound of claim 1, wherein any atom not designated as deuterium is present at its natural isotopic abundance.
    • 16. A composition comprising an effective amount of a compound of claim 1, or a pharmaceutically acceptable salt of said compound; and an acceptable carrier.
    • 17. A method of treating a disease selected from the group consisting of psoriasis and psoriatic arthritis in a patient in need thereof comprising administering to the patient an effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof.
      • 18. The method of claim 17, wherein psoriasis is plaque-type psoriasis or refractory psoriasis.
    • 19. The compound of claim 1, wherein the compound of Formula I is a compound of Formula Ia, having predominantly the (S) configuration at the carbon attached to Y2:
    • 20. The compound of claim 1, wherein the compound of Formula I is a compound of Formula Ib, having predominantly the (R) configuration at the carbon attached to Y2:
  • 11. A compound selected from the group consisting of :
    • 12. A compound of claim 11, having predominantly the (S) configuration.
    • 13. A compound of claim 11, having predominantly the (R) configuration.
  • 14. A compound selected from the group consisting of