Patexia. Research
Patent No. US 08143003
Issue Date Mar 27, 2012
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Patent 08143003 - Method for detecting oral squamous-cell carcinoma > Claims

  • 1. A method for detecting oral squamous-cell carcinoma in a patient, which comprises detecting deletion of a MTNR1A gene or hypermethylation of the MTNR1A gene in an oral-cavity-derived cell from the patient, wherein deletion of the MTNR1A gene or hypermethylation of the MTNR1A gene in an oral-cavity-derived cell from the patient is indicative of oral squamous-cell carcinoma.
    • 2. The method for detecting oral squamous-cell carcinoma in a patient according to claim 1, wherein deletion of the MTNR1A gene or hypermethylation of the MTNR1A gene in the oral-cavity-derived cell from the patient is detected using a DNA chip method, a Southern blot method, a Northern blot method, a real-time RT-PCR method, a FISH method, a CGH method, an array CGH method, a bisulfite sequencing method, or a COBRA method.