Patent Application - Multivalent vaccines comprising recombinant viral vectors > Summary

Patent Application No. US 20110281347

Published on Nov 17, 2011

Application No. 13/134190

Filed on May 31, 2011

Priority Date -

Havenga, Menzo Jans Emco - Alphen aan den Rijn, NL (25)

Described are vaccines comprising recombinant vectors, such as recombinant adenoviruses. The vectors comprise heterologous nucleic acids encoding at least two antigens from one or more tuberculosis-causing bacilli. Also described is the use of specific protease recognition sites linking antigens through which the encoded antigens are separated upon cleavage. After cleavage, the antigens contribute to the immune response in a separate manner. The recombinant vectors may comprise a nucleic acid encoding the protease cleaving the linkers and separating the antigens. Also described is the use of genetic adjuvants encoded by the recombinant vectors, wherein such genetic adjuvants may also be cleaved through the presence of the cleavable linkers and the specific protease.