Search
Patexia Research
Issue Date Dec 10, 2015
Claim this application
PDF Unavailable

Patent Application - COMBINATION > Claims

  • 1. A combination comprising:n(i) a compound of formula (I)
    • 2. A combination according to claim 1 wherein compound (I) is in the form of the propanediol salt and the compound (II) is in the form of the methanesulfonate salt.
    • 3. A combination kit comprising a combination according claim 1 together with a pharmaceutically acceptable carrier or carriers.
    • 7. A pharmaceutical composition comprising a combination according to claim 1 together with a pharmaceutically acceptable diluent or carrier.
  • 4. (canceled)
  • 5. (canceled)
  • 6. (canceled)
  • 8. A method of treating cancer in a human in need thereof which comprises the administration of a therapeutically effective amount ofn(i) a compound of formula (I)
    • 9. The method of claim 8, wherein the cancer is selected from head and neck cancer, breast cancer, lung cancer, colon cancer, ovarian cancer, prostate cancer, gliomas, glioblastoma, astrocytomas, glioblastoma multiforme, Bannayan-Zonana syndrome, Cowden disease, Lhermitte-Duclos disease, inflammatory breast cancer, Wilm's tumor, Ewing's sarcoma, Rhabdomyosarcoma, ependymoma, medulloblastoma, kidney cancer, liver cancer, melanoma, pancreatic cancer, sarcoma, osteosarcoma, giant cell tumor of bone, thyroid cancer, lymphoblastic T cell leukemia, Chronic myelogenous leukemia, Chronic lymphocytic leukemia, Hairy-cell leukemia, acute lymphoblastic leukemia, acute myelogenous leukemia, AML, Chronic neutrophilic leukemia, Acute lymphoblastic T cell leukemia, plasmacytoma, Immunoblastic large cell leukemia, Mantle cell leukemia, Multiple myeloma Megakaryoblastic leukemia, multiple myeloma, acute megakaryocytic leukemia, promyelocytic leukemia, Erythroleukemia, malignant lymphoma, hodgkins lymphoma, non-hodgkins lymphoma, lymphoblastic T cell lymphoma, Burkitt's lymphoma, follicular lymphoma, neuroblastoma, bladder cancer, urothelial cancer, vulval cancer, cervical cancer, endometrial cancer, renal cancer, mesothelioma, esophageal cancer, salivary gland cancer, hepatocellular cancer, gastric cancer, nasopharangeal cancer, buccal cancer, cancer of the mouth, GIST (gastrointestinal stromal tumor), and testicular cancer.
      • 10. The method of claim 9, wherein the cancer is melanoma.
        • 11. The method of claim 10, wherein compound (i) is in the form of the propanediol salt and the compound (ii) is in the form of the methanesulfonate salt.
  • 12. A method of re-sensitizing BRAF inhibitor resistant melanoma brain metastases comprising the administration of a therapeutically effective amount ofn(i) a compound of formula (I)
Menu