Gene helps regulate body weight

Researchers at the University of Rhode Island made an unexpected discovery when researching a brain protein called RGS9 2. The scientists were investigating RGS9 2’s role in involuntary movements that can be a side effect of drugs for Parkinson’s and schizophrenia. But, when studying this protein in mice, the researchers noted that mice with a gene variation that lowers RGS9 2 levels had a higher body mass index. Mice who had the RGS9 2 gene deleted also weighed more than normal mice. Additionally, when the RGS9-2 protein was over-expressed in rats, the rats lost weight. The researchers believe that RGS9 2 levels affect weight through influence on metabolic rates. While this finding has implications for millions struggling with their weight, the researchers are also still pursuing the initial research on drug side effects linked with RGS9 2. They are developing methods to predict who is more likely to experience involuntary movements as a side effect and tailor treatment accordingly.